Frequently Asked Questions
Who is eligible to become a member?
Researchers based in the UK who work at a higher education institution, research council institute or independent research organisation are eligible to apply to become a member of the MRC Mouse Network Consortium.
What resources are available?
Members can access IMPC mouse knockout lines from MRC Harwell, as well as tissues and samples from these lines, and nominate genes for new knockout mouse lines. They can receive email updates on their genes of interest, attend networking events and discuss relevant issues with other experts in their consortia via the forum. Please note that we have a turn-around time of approximately 18 months and cannot guarantee that a nominated knockout mouse line will be produced.
What if a line cannot be produced?
The IMPC working under high-throughput conditions, and therefore can only afford to carry out a single attempt for each gene to produce a knockout line. Although we have strict quality control measures in place, ES cell targeting, chimera production, germ-line transmission, fecundity and lethality will all vary between lines. A nominated gene therefore has approximately a 50% chance of making through the full program, and many lines cannot be produced or do not reach adulthood.
Where can I find out more about the IMPC?
The MRC Mouse Network is solely coordinated by MRC Harwell. However, we are part of the much larger IMPC, and are working alongside research institutes all across the world. For more about the consortium aims, members, knockout mouse lines and data, please visit the IMPC portal.