Our research programmes span an entire lifetime, from the intricate mechanisms that occur in the earliest stages of embryonic development to the underlying causes of diseases of ageing. We have seven research programmes focused on lifetime studies that investigate the genetics and functional genomics underlying development and disease.
We established and manage the Harwell Ageing Screen, a unique large-scale project to study the genetics of ageing and age-related diseases such as heart disease, diabetes and cancer.
We investigate the genetic basis of mammalian behaviour to improve our understanding of how the central nervous system functions in circadian rhythms, sleep and psychiatric disease.
We identify new genetic pathways involved in neurodegeneration using mouse models of relevant diseases. In particular, we focus on genes involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
It is estimated that over 250 million people worldwide suffer moderate to profound hearing loss, of which half have a genetic basis. We study the genetics that underlie the process of hearing to advance our knowledge of deafness and improve treatments.
We are investigating embryonic gonad development and abnormalities of this process that cause disease. We mainly study 46,XY gonadal dysgenesis, in which XY individuals develop as females, by investigating the underlying genetics of this condition.
Cilia are important in a wide range of processes, including development. We are interested in what happens when cilia malfunction and the impact this has on both embryonic development and adult disease.
Over three million people in the UK are diagnosed with diabetes, a figure set to rise, and around 90% of these cases have type 2 diabetes. We identify and investigate genes involved in this condition in order to improve treatments.