ADVANCE training centre

Location

ADVANCE training centre
MRC Harwell

Organizer

The Advance Team
Phone
+44 (0)1235 841438
Email
training@har.mrc.ac.uk

Introduction to Genetically Altered Mice

Date

Apr 04 - 05 2022

Time

10:00 am - 4:00 pm

Cost

£500.00

Who is this for? 

  • Animal Technicians
  • Early Career Researchers
  • PhD Students

This 2-day course will cover Mendelian gene inheritance as well as aspects of more complex genetics intended to inform breeding strategies and calculations in establishing new genetically altered lines.

After the course, you will be able to:

  • Understand Mendelian gene inheritance
  • Predict the outcomes of genetic crosses
  • Have a working knowledge of the genetic background of mouse strains
  • Understand how to maintain the genetic integrity of inbred lines
  • Plan breeding schemes
  • Perform multiple allele inheritance calculations
  • Understand how Genetically Altered lines can be established from modern transgenic technologies

Hourly Schedule

Day 1

10:00 - 11:30
Introductions / Session 1
Registration. Orientation. Coffee. Icebreaker and H&S. Macromolecules. History of DNA. DNA to protein.
11:30 - 12:15
Session 2
Protiens
12:15 - 13:00
Lunch
Lunch is provided
13:00 - 13:30
Session 3
DNA to Disease Mechanism
13:30 - 14:30
Session 4
Inbred mice - why mice and why inbred?
14:30 - 14:50
Break
Refreshments provided
14:50 - 16:00
Session 5
Genetics drift. Nomenclature. Inbred strain difference. Outbred strains.

Day 2

9:30 - 10:30
Session 1
Cells, chromosomes, DNA replication. Mitosis and meiosis
10:30 - 11:00
Session 2
Dominant, recessive and human disorders
11:00 - 12:15
Session 3
Making genetic modifications
12:15 - 13:00
Lunch
Lunch is provided
13:00 - 13:45
Session 4
Coat colour and single allele inheritance
13:45 - 14:45
Session 5
Backcrossing and cohort breeding
14:45 - 15:00
Break
Refreshments provided
15:00 - 16:00
Session 6
Colony management. End of course

The event is finished.

  • This course was fantastic. Really pleased with how it was taught. Shelly did a great job, appreciated Rosie’s help with the calculations and Sara’s topics. Thank you.

    14th Oct 2019

  • I found the course very informative. I am still fairly new to transgenic colonies and still have lots more to learn. Very much enjoyed the course thank you.

    14th Oct 2019

  • I really enjoyed the course and found it very useful. The pace was generally good although it did increase towards the end of the second day as time was running out. I don’t think there is anything specifically to improve.

    14th Oct 2019

  • Good refresher course

    14th Oct 2019

  • Great course!

    14th Oct 2019

    Submit to register for: Introduction to Genetically Altered Mice