International Mouse Phenotyping Consortium

The International Mouse Phenotyping Consortium (IMPC) aims to determine the function of every protein-coding gene in the mouse genome.

The IMPC is a global effort comprised of scientists from 21 research institutions around the world. To achieve this, the IMPC is systematically switching off or ‘knocking out’ each of the roughly 20,000 genes that make up the mouse genome. Subsequently, the knock out mice undergo standardised physiological tests (phenotyping tests) across a range of biological systems in order to infer gene function, before the data is made freely available to the research community via the IMPC website.