Consortium Papers

Publications detailing the collaborative efforts of the MLC with international consortia involved in the targeted construction and phenotyping of mutant mouse lines, as well as the archiving and distribution of mouse disease models and disease gene discovery. These include the IMPC, EUMODIC and INFRAFRONTIER.

Model matchmaking via the Solve-RD Rare Disease Models & Mechanisms Network (RDMM-Europe)

Ellwanger, K., Brill, J. A., de Boer, E., Efthymiou, S., Elgersma, Y., Icmat, M., Lecoquierre, F., Lobato, A. G., Morleo, M., Ori, M., Schaffer, A. E., Vitobello, A., Wells, S., Yalcin, B., Zhai, R. G., Sturm, M., Zurek, B., Graessner, H., Bermejo-Sánchez, E., Evangelista, T., Hoogerbrugge, N., Nigro, V., Schüle, R., Verloes, A., Brunner, H., Campeau, P. M., Lasko, P., Riess, O.

(2024) , Lab Anim , 53 , 161-165

10.1038/s41684-024-01395-2

PMC11216991

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Improving laboratory animal genetic reporting: LAG-R guidelines

Teboul, L., Amos-Landgraf, J., Benavides, F. J., Birling, M. C., Brown, S. D. M., Bryda, E., Bunton-Stasyshyn, R., Chin, H. J., Crispo, M., Delerue, F., Dobbie, M., Franklin, C. L., Fuchtbauer, E. M., Gao, X., Golzio, C., Haffner, R., Hérault, Y., Hrabe de Angelis, M., Lloyd, K. C. K., Magnuson, T. R., Montoliu, L., Murray, S. A., Nam, K. H., Nutter, L. M. J., Pailhoux, E., Pardo Manuel de Villena, F., Peterson, K., Reinholdt, L., Sedlacek, R., Seong, J. K., Shiroishi, T., Smith, C., Takeo, T., Tinsley, L., Vilotte, J. L., Warming, S., Wells, S., Whitelaw, C. B., Yoshiki, A., Asian Mouse Mutagenesis Resource Assocation, CELPHEDIA infrastructure, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technologies, Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC- Rat Resource and Research Center, Pavlovic, G.

(2024) , Nat Commun , 15 , 5574

10.1038/s41467-024-49439-y

PMC11220107

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Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Elrick, H., Peterson, K. A., Willis, B. J., Lanza, D. G., Acar, E. F., Ryder, E. J., Teboul, L., Kasparek, P., Birling, M. C., Adams, D. J., Bradley, A., Braun, R. E., Brown, S. D., Caulder, A., Codner, G. F., DeMayo, F. J., Dickinson, M. E., Doe, B., Duddy, G., Gertsenstein, M., Goodwin, L. O., Hérault, Y., Lintott, L. G., Lloyd, K. C. K., Lorenzo, I., Mackenzie, M., Mallon, A. M., McKerlie, C., Parkinson, H., Ramirez-Solis, R., Seavitt, J. R., Sedlacek, R., Skarnes, W. C., Smedley, D., Wells, S., White, J. K., Wood, J. A., Murray, S. A., Heaney, J. D., Nutter, L. M. J.

(2024) , Sci Rep , 14 , 22626

10.1038/s41598-024-72418-8

PMC11443006

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The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease

Groza, T., Gomez, F. L., Mashhadi, H. H., Muñoz-Fuentes, V., Gunes, O., Wilson, R., Cacheiro, P., Frost, A., Keskivali-Bond, P., Vardal, B., McCoy, A., Cheng, T. K., Santos, L., Wells, S., Smedley, D., Mallon, A. M., Parkinson, H.

(2023) , Nucleic Acids Res , 51 , D1038-D1045

10.1093/nar/gkac972

PMID: 36305825

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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

Chee, J. M., Lanoue, L., Clary, D., Higgins, K., Bower, L., Flenniken, A., Guo, R., Adams, D. J., Bosch, F., Braun, R. E., Brown, S. D. M., Chin, H. G., Dickinson, M. E., Hsu, C. W., Dobbie, M., Gao, X., Galande, S., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Mammano, F., Nutter, L. M. J., Parkinson, H., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J. K., Xu, Y., Brooks, B., McKerlie, C., Lloyd, K. C. K., Westerberg, H., Moshiri, A.

(2023) , BMC Biol , 21 , 22

10.1186/s12915-022-01475-0

PMC9898963

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