Consortium Papers

Publications detailing the collaborative efforts of the MLC with international consortia involved in the targeted construction and phenotyping of mutant mouse lines, as well as the archiving and distribution of mouse disease models and disease gene discovery. These include the IMPC, EUMODIC and INFRAFRONTIER.

The Deep Genome Project

Lloyd, K. C. K., Adams, D. J., Baynam, G., Beaudet, A. L., Bosch, F., Boycott, K. M., Braun, R. E., Caulfield, M., Cohn, R., Dickinson, M. E., Dobbie, M. S., Flenniken, A. M., Flicek, P., Galande, S., Gao, X., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Lupski, J. R., Lyonnet, S., Mallon, A. M., Mammano, F., MacRae, C. A., McInnes, R., McKerlie, C., Meehan, T. F., Murray, S. A., Nutter, L. M. J., Obata, Y., Parkinson, H., Pepper, M. S., Sedlacek, R., Seong, J. K., Shiroishi, T., Smedley, D., Tocchini-Valentini, G., Valle, D., Wang, C. L., Wells, S., White, J., Wurst, W., Xu, Y., Brown, S. D. M.

(2020) , Genome Biol , 21 , 18

10.1186/s13059-020-1931-9

PMC6996159

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Human and mouse essentiality screens as a resource for disease gene discovery

Cacheiro, P., Munoz-Fuentes, V., Murray, S. A., Dickinson, M. E., Bucan, M., Nutter, L. M. J., Peterson, K. A., Haselimashhadi, H., Flenniken, A. M., Morgan, H., Westerberg, H., Konopka, T., Hsu, C. W., Christiansen, A., Lanza, D. G., Beaudet, A. L., Heaney, J. D., Fuchs, H., Gailus-Durner, V., Sorg, T., Prochazka, J., Novosadova, V., Lelliott, C. J., Wardle-Jones, H., Wells, S., Teboul, L., Cater, H., Stewart, M., Hough, T., Wurst, W., Sedlacek, R., Adams, D. J., Seavitt, J. R., Tocchini-Valentini, G., Mammano, F., Braun, R. E., McKerlie, C., Herault, Y., de Angelis, M. H., Mallon, A. M., Lloyd, K. C. K., Brown, S. D. M., Parkinson, H., Meehan, T. F., Smedley, D.

(2020) , Nat Commun , 11 , 655

10.1038/s41467-020-14284-2

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Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Rozman, J., Rathkolb, B., Oestereicher, M. A., Schutt, C., Ravindranath, A. C., Leuchtenberger, S., Sharma, S., Kistler, M., Willershauser, M., Brommage, R., Meehan, T. F., Mason, J., Haselimashhadi, H., Hough, T., Mallon, A. M., Wells, S., Santos, L., Lelliott, C. J., White, J. K., Sorg, T., Champy, M. F., Bower, L. R., Reynolds, C. L., Flenniken, A. M., Murray, S. A., Nutter, L. M. J., Svenson, K. L., West, D., Tocchini-Valentini, G. P., Beaudet, A. L., Bosch, F., Braun, R. B., Dobbie, M. S., Gao, X., Herault, Y., Moshiri, A., Moore, B. A., Kent Lloyd, K. C., McKerlie, C., Masuya, H, Tanaka, N., Flicek, P., Parkinson, H. E., Sedlacek, R., Seong, J. K., Wang, C. L., Moore, M., Brown, S. D., Tschop, M. H., Wurst, W., Klingenspor, M., Wolf, E., Beckers, J., Machicao, F., Peter, A., Staiger, H., Haring, H. U., Grallert, H., Campillos, M., Maier, H., Fuchs, H., Gailus-Durner, V., Werner, T., Hrabe de Angelis, M.

(2018) , Nat Commun , 9 , 288

10.1038/s41467-017-01995-2

PMC5773596

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Identification of genes required for eye development by high-throughput screening of mouse knockouts

Moore, B. A., Leonard, B. C., Sebbag, L., Edwards, S. G., Cooper, A., Imai, D. M., Straiton, E., Santos, L., Reilly, C., Griffey, S. M., Bower, L., Clary, D., Mason, J., Roux, M. J., Meziane, H., Herault, Y., McKerlie, C., Flenniken, A. M., Nutter, L. M. J., Berberovic, Z., Owen, C., Newbigging, S., Adissu, H., Eskandarian, M., Hsu, C. W., Kalaga, S., Udensi, U., Asomugha, C., Bohat, R., Gallegos, J. J., Seavitt, J. R., Heaney, J. D., Beaudet, A. L., Dickinson, M. E., Justice, M. J., Philip, V., Kumar, V., Svenson, K. L., Braun, R. E., Wells, S., Cater, H., Stewart, M., Clementson-Mobbs, S., Joynson, R., Gao, X., Suzuki, T., Wakana, S., Smedley, D., Seong, J. K., Tocchini-Valentini, G., Moore, M., Fletcher, C., Karp, N., Ramirez-Solis, R., White, J. K., de Angelis, M. H., Wurst, W., Thomasy, S. M., Flicek, P., Parkinson, H., Brown, S. D. M., Meehan, T. F., Nishina, P. M., Murray, S. A., Krebs, M. P., Mallon, A. M., Lloyd, K. C. K., Murphy, C. J., Moshiri, A.

(2018) , Commun Biol , 1 , 236

10.1038/s42003-018-0226-0

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Prevalence of sexual dimorphism in mammalian phenotypic traits

Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., Dickinson, M. E., Flenniken, A. M., Fuchs, H., Angelis, M. H., Gao, X., Guo, S., Greenaway, S., Heller, R., Herault, Y., Justice, M. J., Kurbatova, N., Lelliott, C. J., Lloyd, K. C. K., Mallon, A. M., Mank, J. E., Masuya, H., McKerlie, C., Meehan, T. F., Mott, R. F., Murray, S. A., Parkinson, H., Ramirez-Solis, R., Santos, L., Seavitt, J. R., Smedley, D., Sorg, T., Speak, A. O., Steel, K. P., Svenson, K. L., Wakana, S., West, D., Wells, S., Westerberg, H., Yaacoby, S., White, J. K.

(2017) , Nat Commun , 8 , 15475

10.1038/ncomms15475

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