Methods Development
The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.
When all is not lost: considering genetic compensation in laboratory animals
Bunton-Stasyshyn, R. K. A., Wells, S., Teboul, L.
Microhomologies are prevalent at Cas9-induced larger deletions
Owens, D. D. G., Caulder, A., Frontera, V., Harman, J. R., Allan, A. J., Bucakci, A., Greder, L., Codner, G. F., Hublitz, P., McHugh, P. J., Teboul, L., de Bruijn, MFTR
Response to “Unexpected mutations after CRISPR-Cas9 editing in vivo”
Nutter, L. M. J., Heaney, J. D., Lloyd, K. C. K., Murray, S. A., Seavitt, J. R., Skarnes, W. C., Teboul, L., Brown, S. D. M., Moore, M.
Long term maintenance of frozen mouse spermatozoa at -80 degrees C
Raspa, M., Fray, M., Paoletti, R., Montoliu, L., Giuliani, A., Scavizzi, F.
High-throughput mouse phenomics for characterizing mammalian gene function
Brown, S. D. M., Holmes, C. C., Mallon, A. M., Meehan, T. F., Smedley, D., Wells, S.