Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
Garone, M. G., Birsa, N., Rosito, M., Salaris, F., Mochi, M., de Turris, V., Nair, R. R., Cunningham, T. J., Fisher, E. M. C., Morlando, M., Fratta, P., Rosa, A.
A novel model of nephrotic syndrome results from a point mutation in Lama5 and is modified by genetic background
Falcone, S., Nicol, T., Blease, A., Randles, M. J., Angus, E., Page, A., Tam, F. W. K., Pusey, C. D., Lennon, R., Potter, P. K.
A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits
Cleverley, K., Lee, W. C., Mumford, P., Collins, T., Rickman, M., Cunningham, T. J., Cleak, J., Mianne, J., Szoke-Kovacs, Z., Stewart, M., Teboul, L., Maduro, C., Wells, S., Wiseman, F. K., Fisher, E. M. C.
Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism
Gaynor, K. U., Grigorieva, I. V., Mirczuk, S. M., Piret, S., Kooblall, K. G., Stevenson, M., Rizzoti, K., Bowl, M. R., Nesbit, M. A., Christie, P. T., Fraser, W. D., Hough, T., Whyte, M. P., Lovell-Badge, R., Thakker, R.
Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13
Livermore, C., Simon, M., Reeves, R., Stévant, I., Nef, S., Pope, M., Mallon, A. M., Wells, S., Warr, N., Greenfield, A.