Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not
Williams, J. L., Paudyal, A., Awad, S., Nicholson, J., Grzesik, D., Botta, J., Meimaridou, E., Maharaj, A. V., Stewart, M., Tinker, A., Cox, R. D., Metherell, L. A.
Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function
Findlay, A. S., McKie, L., Keighren, M., Clementson-Mobbs, S., Sanchez-Pulido, L., Wells, S., Cross, S. H., Jackson, I. J.
Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations
Bryant, D., Seda, M., Peskett, E., Maurer, C., Pomeranz, G., Ghosh, M., Hawkins, T. A. Cleak, J., Datta, S., Hariri, H., Eckert, K. M., Jafree, D. J., Walsh, C., Demetriou, C., Ishida, M., Alemán-Charlet, C., Vestito, L., Seselgyte, R., McDonald, J. G., Bitner-Glindzicz, M., Hemberger, M., Rihel, J., Teboul, L., Henne, W. M., Jenkins, D., Moore, G. E., Stanier, P.
Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells
Jeng, J. Y., Johnson, S. L., Carlton, A. J., De Tomasi, L., Goodyear, R. J., De Faveri, F., Furness, D. N., Wells, S., Brown, S. D. M., Holley, M. C., Richardson, G. P., Mustapha, M., Bowl, M. R., Marcotti, W.
The development of a high throughput drug-responsive model of white adipose tissue comprising adipogenic 3T3-L1 cells in a 3D matrix
Graham, A. D., Pandey, R., Tsancheva, V. S., Candeo, A., Botchway, S. W., Allan, A. J., Teboul, L., Madi, K., Babra, T. S., Zolkiewski, L. A. K., Xue, X., Bentley, L., Gannon, J., Olof, S. N., Cox, R. D.