Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
A genetic modifier suggests that endurance exercise exacerbates Huntington’s Disease
Corrochano, S., Blanco, G., Williams, D., Wettstein, J., Simon, M., Kumar, S., Moir, L., Agnew, T., Stewart, M., Landman, A., Kotiadis, V. N., Duchen, M. R., Wackerhage, H., Rubinsztein, D. C., Brown, S. D. M., Acevedo-Arozena, A.
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
Bilanges, B., Alliouachene, S., Pearce, W., Morelli, D., Szabadkai, G., Chung, Y. L., Chicanne, G., Valet, C., Hill, J. M., Voshol, P. J., Collinson, L., Peddie, C., Ali, K., Ghazaly, E., Rajeeve, V., Trichas, G., Srinivas, S., Chaussade, C., Salamon, R. S., Backer, J. M., Scudamore, C. L., Whitehead, M. A., Keaney, E. P., Murphy, L. O., Semple, R. K., Payrastre, B., Tooze, S. A., Vanhaesebroeck, B.
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Berenjeno, I. M., Pineiro, R., Castillo, S. D., Pearce, W., McGranahan, N., Dewhurst, S. M., Meniel, V., Birkbak, N. J., Lau, E., Sansregret, L., Morelli, D., Kanu, N., Srinivas, S., Graupera, M., Parker, V. E. R., Montgomery, K. G., Moniz, L. S., Scudamore, C. L., Phillips, W. A., Semple, R. K., Clarke, A., Swanton, C., Vanhaesebroeck, B.
N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice
Gorvin, C. M., Rogers, A., Stewart, M., Paudyal, A., Hough, T. A., Teboul, L., Wells, S., Brown, S. D., Cox, R. D., Thakker, R. V.
Mutant mice with calcium-sensing receptor (CaSR) activation have hyperglycemia, that is rectified by calcilytic therapy
Babinsky, V. N., Hannan, F. M., Ramracheya, R. D., Zhang, Q., Nesbit, M. A., Hugill, A., Bentley, L., Hough, T. A., Joynson, E., Stewart, M., Aggarwal, A., Prinz-Wohlgenannt, M., Gorvin, C. M., Kallay, E., Wells, S., Cox, R. D., Richards, D., Rorsman, P., Thakker, R. V.