Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
A mutation in Nischarin causes otitis media via LIMK1 and NF-kappaB pathways
Crompton, M., Purnell, T., Tyrer, H. E., Parker, A., Ball, G., Hardisty-Hughes, R. E., Gale, R., Williams, D., Dean, C. H., Simon, M. M., Mallon, A. M., Wells, S., Bhutta, M. F., Burton, M. J., Tateossian, H., Brown, S. D. M.
Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway
Esapa, C. T., Piret, S. E., Nesbit, M. A., Loh, N. Y., Thomas, G., Croucher, P. I., Brown, M. A., Brown, S. D., Cox, R. D., Thakker, R. V.
Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy
Madeo, M., Stewart, M., Sun, Y., Sahir, N., Wiethoff, S., Chandrasekar, I., Yarrow, A., Rosenfeld, J. A., Yang, Y., Cordeiro, D., McCormick, E. M., Muraresku, C. C., Jepperson, T. N., McBeth, L. J., Seidahmed, M. Z., El Khashab, H. Y., Hamad, M., Azzedine, H., Clark, K., Corrochano, S., Wells, S., Elting, M. W., Weiss, M. M., Burn, S., Myers, A., Landsverk, M., Crotwell, P. L., Waisfisz, Q., Wolf, N. I., Nolan, P. M., Padilla-Lopez, S., Houlden, H., Lifton, R., Mane, S., Singh, B. B., Falk, M. J., Mercimek-Mahmutoglu, S., Bilguvar, K., Salih, M. A., Acevedo-Arozena, A., Kruer, M. C.
Lack of transmission of murine norovirus to mice via in vitro fertilization, intracytoplasmic sperm injection, and ovary transplantation
Raspa, M., Mahabir, E., Fray, M., Volland, R., Scavizzi, F.
Inactivation of class II PI3K-C2alpha induces leptin resistance, age-dependent insulin resistance and obesity in male mice
Alliouachene, S., Bilanges, B., Chaussade, C., Pearce, W., Foukas, L. C., Scudamore, C. L., Moniz, L. S., Vanhaesebroeck, B.