Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
Nicod, J., Davies, R. W., Cai, N., Hassett, C., Goodstadt, L., Cosgrove, C., Yee, B. K., Lionikaite, V., McIntyre, R. E., Remme, C. A., Lodder, E. M., Gregory, J. S., Hough, T., Joynson, R., Phelps, H., Nell, B., Rowe, C., Wood, J., Walling, A., Bopp, N., Bhomra, A., Hernandez-Pliego, P., Callebert, J., Aspden, R. M., Talbot, N. P., Robbins, P. A., Harrison, M., Fray, M., Launay, J. M., Pinto, Y. M., Blizard, D. A., Bezzina, C. R., Adams, D. J., Franken, P., Weaver, T., Wells, S., Brown, S. D., Potter, P. K., Klenerman, P., Lionikas, A., Mott, R., Flint, J.
Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination
Warr, N., Siggers, P., Carre, G. A., Wells, S., Greenfield, A.
Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles
Elshorbagy, A. K., Jerneren, F., Scudamore, C. L., McMurray, F., Cater, H., Hough, T., Cox, R., Refsum, H.
Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues
Al-Jazzar, A., Javaheri, B., Prideaux, M., Boyde, A., Scudamore, C. L., Cherifi, C., Hay, E., Hopkinson, M., Boyd, M., Cohen-Solal, M., Farquharson, C., Pitsillides, A. A.
Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration
Joyce, P. I., Fratta, P., Landman, A. S., McGoldrick, P., Wackerhage, H., Groves, M., Busam, B. S., Galino, J., Corrochano, S., Beskina, O. A., Esapa, C., Ryder, E., Carter, S., Stewart, M., Codner, G., Hilton, H., Teboul, L., Tucker, J., Lionikas, A., Estabel, J., Ramirez-Solis, R., White, J. K., Brandner, S., Plagnol, V., Bennet, D. L., Abramov, A. Y., Greensmith, L., Fisher, E. M., Acevedo-Arozena, A.