Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum
Bucknor, E. M. V., Johnson, E., Efthymiou, S., Alvi, J. R., Sultan, T., Houlden, H., Maroofian, R., Karimiani, E. G., Finelli, M. J., Oliver, P. L.
Naturally sterile Mus spretus hybrids are suitable for the generation of pseudopregnant embryo transfer recipients
Preece, C., Biggs, D., Grencis, E., Jackson, M. S., Allen, S., Fray, M., Adamson, A., Davies, B.
Mutant Tbl1x male mice have a short lifespan and do not breed: unexpected findings
Hu, Y., Codner, G. F., Stewart, M., La Fleur, S. E., van Trotsenburg, P. A., Fliers, E., Hennekam, R. C., Boelen, A.
Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1(G93A) mice by reducing inflammatory pathways in the adipose tissue
Fernández-Beltrán, L. C., Ali, Z., Larrad-Sanz, A., Lopez-Carbonero, J. I., Godoy-Corchuelo, J. M., Jimenez-Coca, I., Garcia-Toledo, I., Bentley, L., Gomez-Pinedo, U., Matias-Guiu, J. A., Gil-Moreno, M. J., Matias-Guiu, J., Corrochano, S.
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines
Elrick, H., Peterson, K. A., Willis, B. J., Lanza, D. G., Acar, E. F., Ryder, E. J., Teboul, L., Kasparek, P., Birling, M. C., Adams, D. J., Bradley, A., Braun, R. E., Brown, S. D., Caulder, A., Codner, G. F., DeMayo, F. J., Dickinson, M. E., Doe, B., Duddy, G., Gertsenstein, M., Goodwin, L. O., Hérault, Y., Lintott, L. G., Lloyd, K. C. K., Lorenzo, I., Mackenzie, M., Mallon, A. M., McKerlie, C., Parkinson, H., Ramirez-Solis, R., Seavitt, J. R., Sedlacek, R., Skarnes, W. C., Smedley, D., Wells, S., White, J. K., Wood, J. A., Murray, S. A., Heaney, J. D., Nutter, L. M. J.