Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
Pharmacological Inhibition of FTO
McMurray, F., Demetriades, M., Aik, W., Merkestein, M., Kramer, H., Andrew, D. S., Scudamore, C. L., Hough, T. A., Wells, S., Ashcroft, F. M., McDonough, M. A., Schofield, C. J., Cox, R. D.
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic beta Cells
Arredouani, A., Ruas, M., Collins, S. C., Parkesh, R., Clough, F., Pillinger, T., Coltart, G., Rietdorf, K., Royle, A., Johnson, P., Braun, M., Zhang, Q., Sones, W., Shimomura, K., Morgan, A. J., Lewis, A. M., Chuang, K. T., Tunn, R., Gadea, J., Teboul, L., Heister, P. M., Tynan, P. W., Bellomo, E. A., Rutter, G. A., Rorsman, P., Churchill, G. C., Parrington, J., Galione, A.
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance
Hugill, A. J., Stewart, M. E., Yon, M. A., Probert, F., Cox, I. J., Hough, T. A., Scudamore, C. L., Bentley, L., Wall, G., Wells, S. E., Cox, R. D.
Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread
Wong, P. P., Demircioglu, F., Ghazaly, E., Alrawashdeh, W., Stratford, M. R., Scudamore, C. L., Cereser, B., Crnogorac-Jurcevic, T., McDonald, S., Elia, G., Hagemann, T., Kocher, H. M., Hodivala-Dilke, K. M.
A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity
Joyce, P. I., McGoldrick, P., Saccon, R. A., Weber, W., Fratta, P., West, S. J., Zhu, N., Carter, S., Phatak, V., Stewart, M., Simon, M., Kumar, S., Heise, I., Bros-Facer, V., Dick, J., Corrochano, S., Stanford, M. J., Luong, T. V., Nolan, P. M., Meyer, T., Brandner, S., Bennett, D. L., Ozdinler, P. H., Greensmith, L., Fisher, E. M., Acevedo-Arozena, A.