Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
The parenting hub of the hypothalamus is a focus of imprinted gene action
Higgs, M. J., Webberley, A. E., Allan, A. J., Talat, M., John, R. M., Isles, A. R.
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice
Brown, N., Finnon, R., Finnon, P., McCarron, R., Cruz-Garcia, L., O'Brien, G., Herbert, E., Scudamore, C. L., Morel, E., Badie, C.
Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation
Bowen, E. E., Hurcombe, J. A., Barrington, F., Keir, L. S., Farmer, L. K., Wherlock, M. D., Ortiz-Sandoval, C. G., Bruno, V., Bohorquez-Hernandez, A., Diatlov, D., Rostam-Shirazi, N., Wells, S., Stewart, M., Teboul, L., Lay, A. C., Butler, M. J., Pope, R. J. P., Larkai, E. M. S., Morgan, B. P., Moppett, J., Satchell, S. C., Welsh, G. I., Walker, P. D., Licht, C., Saleem, M. A., Coward, R. J. M.
Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations
Ali, Z., Godoy-Corchuelo, J. M., Martins-Bach, A. B., Garcia-Toledo, I., Fernández-Beltrán, L. C., Nair, R. R., Spring, S., Nieman, B. J., Jimenez-Coca, I., Bains, R. S., Forrest, H., Lerch, J. P., Miller, K., Fisher, E. M. C., Cunningham, T. J., Corrochano, S.
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development
Chee, J. M., Lanoue, L., Clary, D., Higgins, K., Bower, L., Flenniken, A., Guo, R., Adams, D. J., Bosch, F., Braun, R. E., Brown, S. D. M., Chin, H. G., Dickinson, M. E., Hsu, C. W., Dobbie, M., Gao, X., Galande, S., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Mammano, F., Nutter, L. M. J., Parkinson, H., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J. K., Xu, Y., Brooks, B., McKerlie, C., Lloyd, K. C. K., Westerberg, H., Moshiri, A.