Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits

Cleverley, K., Lee, W. C., Mumford, P., Collins, T., Rickman, M., Cunningham, T. J., Cleak, J., Mianne, J., Szoke-Kovacs, Z., Stewart, M., Teboul, L., Maduro, C., Wells, S., Wiseman, F. K., Fisher, E. M. C.

(2021) , Mamm Genome , 32 , 94-103

10.1007/s00335-021-09864-6

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Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism

Gaynor, K. U., Grigorieva, I. V., Mirczuk, S. M., Piret, S., Kooblall, K. G., Stevenson, M., Rizzoti, K., Bowl, M. R., Nesbit, M. A., Christie, P. T., Fraser, W. D., Hough, T., Whyte, M. P., Lovell-Badge, R., Thakker, R.

(2020) , Endocr Connect , 9 , 173-186

10.1530/ec-19-0478

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Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13

Livermore, C., Simon, M., Reeves, R., Stévant, I., Nef, S., Pope, M., Mallon, A. M., Wells, S., Warr, N., Greenfield, A.

(2020) , Genetics , 214 , 467-477

10.1534/genetics.119.302786

PMC7017026

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Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not

Williams, J. L., Paudyal, A., Awad, S., Nicholson, J., Grzesik, D., Botta, J., Meimaridou, E., Maharaj, A. V., Stewart, M., Tinker, A., Cox, R. D., Metherell, L. A.

(2020) , Life Sci Alliance , 3 , e201900593

10.26508/lsa.201900593

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Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function

Findlay, A. S., McKie, L., Keighren, M., Clementson-Mobbs, S., Sanchez-Pulido, L., Wells, S., Cross, S. H., Jackson, I. J.

(2020) , Sci Rep , 10 , 437

10.1038/s41598-019-57398-4

PMC6965129

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