ADVANCE training centre

Location

ADVANCE training centre
MRC Harwell

Organizer

The Advance Team
Phone
+44 (0)1235 841438
Email
training@har.mrc.ac.uk

Advanced Mouse Genetics

Date

May 16 - 17 2022

Time

10:00 am - 5:00 pm

Cost

£500.00

This course explores more complex genetics topics, including multiple allele crosses, complex disease models and will inform breeding strategies and experimental design rather than give a complete guide to the molecular biology. Our team of experienced trainers will support you to examine how different modification lead to different breeding strategies, the importance of genetic consistency and integrity, different modes of inheritance and troubleshooting of reproducibility.

Who is this for?

  • Senior animal technicians
  • Colony managers
  • Researchers

After the course, you will be able to:

  • Understand the foundations of mouse genetics and its use in biomedical research
  • Have a working knowledge of the genetic background of mouse strains
  • Understand how to maintain the genetic integrity of inbred lines
  • Predict the outcomes of genetic crosses involving multiple alleles
  • Understand the fundamentals of different methods that give rise to Genetically Altered mice strains
  • Understand how Genetically Altered lines can be established from modern transgenic technologies
  • Troubleshoot breeding and colony maintenance issues
  • Nomenclature and access to international mouse resources

Hourly Schedule

Day 1

10:00 - 10:30
Introductions
Registration, Orientation, Coffee, Icebreaker and H&S
10:30 - 11:30
Session 1
Inbred strains, genetic drift and diversity in mouse strains
11:30 - 12:15
Session 2
Multiple allele inheritance
12:15 - 13:00
Lunch
Lunch is provided
13:00 - 13:30
Session 3
Chromosomal linkage, GxE
13:30 - 14:30
Session 4
Generating GA mice
14:30 - 14:50
Break
Refreshments provided
14:50 - 16:00
Session 5
Nomenclature, backcrossing, viability statistics

Day 2

09:30 - 10:30
Session 1
Maintaining GA lines. Colony calculations.
10:30 - 11:00
Session 2
Complex cohort breeding
11:00 - 12:15
Session 3
Breeding workshops and discussions
12:15 - 13:00
Lunch
Lunch is provided
13:00 - 13:45
Session 4
Randomisation and blinding
13:45 - 14:45
Session 5
Troubleshooting breeding colony maintenance issues
14:45 - 16:00
Session 6
Nomenclature and accessing international mouse resources. Course end.

The event is finished.

  • Since taking the course last spring I took your advice and have changed the way I am breeding to maintain our colony. This has a huge positive impact on not only the amount of cages in use, cost savings including genotyping, but of course also the 3Rs.

    20th Mar 2019

  • Thank you for the course. It absolutely answered the areas I was looking to know more about. Your in depth knowledge and expertise shone through. Plus, the course delivery was very engaging. I will definitely be recommending the course to my colleagues.

    24th Oct 2019

  • I just wanted to say thank you for the course and it was a pleasure to meet you both. We found the course very useful and informative.

    24th Oct 2019

    Submit to register for: Advanced Mouse Genetics